What is THCP-O?

October, 2023

If you’re a fan of the most powerfully psychoactive cannabinoids in the hemp plant, then there’s a new cannabinoid that you’ll want to add to your list: THCP-O, aka tetrahydrocannabiphorol-O Acetate or THCP-O Acetate.  

As you will see, this is a modified version of the hugely popular tetrahydrocannabiphorol (THC-P) cannabinoid, chemically modified using the same method that converts THC into THC-O-Acetate (THC-O), to offer an even more impressive high for those who crave potency when it comes to their cannabinoid routine. 

To Buy THCP-O Products Click Here


Again, THCP-O or THCP-O Acetate is the acetylated form of THC-P, with THC-P being the most potent cannabinoid in all of hemp. Synthesized for the first time in 2021, the best part about THCP-O is that it boasts a higher binding affinity for the CB1 receptor compared to THC.

What makes THCP-O different from THC-P is that this 7-term side chain cannabinoid is combined with an acetate to enhance its bioavailability to new levels.  If you’ve read up on THC-O before, then this process will sound familiar.  Mixing a cannabinoid with an acetate changes its chemical structure, and therefore enhances how efficiently it “sticks” to CB1 receptors in the brain that are responsible for the high we get from THC.  

In addition, the acetate in THCP-O makes it more chemically stable, which means that it is less likely to break down when exposed to heat. This enhanced stability could make THCPO a more desirable compound for medical and therapeutic applications, as it could potentially have a longer shelf life than other synthetic cannabinoids.


THCPO is a new type of cannabinoid that’s not for the faint-hearted. That’s the inevitable result of adding an acetate to what’s already considered to be the most intoxicating cannabinoid in all of hemp. Its effects are incredibly potent and can take even the most experienced cannabis user on a mind-bending trip to another dimension. If you’re searching for a high that’s next level, THCPO is the cannabinoid for you. With an added acetate, it’s even more potent than THC-P, estimated to be 30 times stronger than delta-9 THC.

THCP-O not only offers a unique and intense high, but it also provides feeling of euphoria that goes above and beyond what we’re used to from other cannabinoids, all while seeming to offer a longer-lasting high as well.  You’ll feel a wave of nostalgic joy wash over you, leaving you feeling happy and carefree for hours on end. Its effects can last up to 8 hours, which is longer than most other cannabinoids.

But beware, THCP-O is not for beginners. It’s a cannabinoid that offers a mind-bending, longer-lasting, and more euphoric high than anything else out there. So if you’re feeling adventurous and want to take your cannabis experience to the next level, give THCP-O a try. Just remember to buckle up and enjoy the ride.


THCP-O Acetate is a completely new cannabinoid – so new, in fact, that most hemp enthusiasts have never even heard of it. That being said, there isn’t yet a standard dosing guide for it. Given its strong potency, we can’t assume that you can compare the ideal milligram amount to that of, say, delta 8 THC even. 

So, if you’re interested in trying a THCP-O product, what we recommend is that you follow the directions on the label.  The manufacturer is required to provide a dosing guideline based on their knowledge of how strong their product is.


As we learn more about THCP-O, we’ll have much more specific dosing guidelines available.  What we can say is that since the cannabinoid is so potent, you don’t want to take as many milligrams in one sitting as you would a milder cannabinoid like delta 8. Because PHC is so strong, doses look to be small amounts, but that is because of how strong the compound is. 

Comparing THCP-O potency to other cannabinoids, however, we can offer a general idea of how much you should take whether you’re a beginner, intermediate, or advanced user, regardless of the product type that’s available:



Of course, as is the case with any new cannabinoid, it’s hard to get into its potential therapeutic uses without clinical research available to reference.  THCP-O Acetate just hasn’t been studied by cannabis researchers yet, so there’s no evidence to point to when discussing what types of benefits this cannabinoid may have outside of getting people high.  

But, at the same time, THCP-O really is just a stronger form of THCP-O. So, if you already experience benefits from taking THC-P, like pain relief, reduced stress and anxiety, improved sleep, relief from nausea and appetite, all of which are properties associated with tetrahydrocannabiphorol, you can basically expect those same effects, only stronger.

As for the safety of THCP-O Acetate, again we have no studies to refer to.  But, there’s no reason to believe it’s unsafe in any way.  In reality, though, acetated cannabinoids are not associated with side effects or risks any more than “regular” cannabinoids like CBD.  Ultimately, cannabinoids are considered nontoxic to the body as they are stored by the endocannabinoid system. THCP-O is structurally similar to many cannabinoids we’ve taken over the years, and to date, there has not been a single toxic compound found in the hemp plant, even in its isolated and concentrated form.  However, taking too much of any psychoactive cannabinoid can cause some mild, short-lived but ultimately non-life-threatening side effects, such as the following:

  • Dizziness
  • Grogginess/drowsiness
  • Anxiety/paranoia
  • Dry eyes
  • Dry mouth
  • Confusion
  • Lack of physical coordination
  • Forgetfulness
  • Increased appetite
  • Low blood pressure


The legality of THCP-O varies from country to country and often depends on how local laws define cannabis and its components. At the time of this article being written, no legislation in Cyprus is singling out THCP-O. 

All cannabis products stemming from Industrial Cannabis (cannabis sativa L.) with THC content below 0.2%, maintain a legal status as they are protected by the Law on The Production and Marketing of Industrial Hemp and the EU legislation, thus making them 100% legal. However, it is always important to check local legislation before consuming or buying THCP-O products.

Because THCP-O products currently are produced from hemp, this makes things even more complicated. According to the Cypriot legislation all hemp derivatives with content below 0.2% THC are legal, with none of the literature making a distinction between naturally occurring and synthesized compounds taken from the plant.


THCP-O is not quite out yet, but when it does come out, you want to be careful, since some companies could be producing low-quality or even fake products, knowing that there’s a growing demand and little supply. However, for now you can buy THCP-O products from trusted online brands such as Klostiki.com. On top of their amazing product, they have amazing customer service and just overall one of the best places to buy THCP-O online


As a rule of thumb, any time you encounter a cannabinoid with “THC” in the name, you should assume that it puts you at risk of failing a drug test.  Why?  Because all THC-based cannabinoids are metabolized by an enzyme called THC-COOH, which is what standard drug tests are seeking to identify in a person’s urine. 

Because THCP-O is particularly potent, there’s good reason to believe that it’s actually more likely to fail a drug test after taking this cannabinoid than it is after taking delta 9 THC.


 THCP-O shows off just how far cannabis technology has come along in recent years, offering a whole new way to experience a powerful, euphoric high derived legally from the hemp plant. It’s safe to say that this cannabinoid is recommended for experienced THC users who aren’t afraid of a high that challenges our understanding of what THC is capable of.  At the present moment there are new THCP-O products releasing daily, which means you could find out what it potentially offers in terms of its “one-of-a-kind high”. Now that THCP-O is making its way onto the market, keep a lookout for the products that are coming to Klostiki

To Buy THCP-O Acetate Products Click Here